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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ASXL1 All Species: 11.82
Human Site: S142 Identified Species: 28.89
UniProt: Q8IXJ9 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IXJ9 NP_056153.2 1541 165432 S142 S C S T E S Q S R P L S N P R
Chimpanzee Pan troglodytes XP_001156134 1531 163916 L135 T E S Q S R P L S N P R D S Y
Rhesus Macaque Macaca mulatta XP_001108038 1589 170584 S190 S C S T E S Q S R P L S N P R
Dog Lupus familis XP_853069 2156 231578 T364 E I A E E V E T S I C E C Q D
Cat Felis silvestris
Mouse Mus musculus P59598 1514 162656 S142 S C S T E S Q S R P L S N P R
Rat Rattus norvegicus XP_002729264 1286 136594
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515168 1882 199357 P228 R D S S L T N P A V Q S K L V
Chicken Gallus gallus Q5ZM88 1412 148651 Y81 V P G R M G V Y T L K K D V P
Frog Xenopus laevis NP_001086579 738 82633
Zebra Danio Brachydanio rerio XP_001341242 1619 172271 S145 S V D E T S S S A S C S T E P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.4 91.1 21.7 N.A. 74 59 N.A. 28.1 26.7 29.2 27.4 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 98.4 93.5 36 N.A. 81.1 66.3 N.A. 41.7 41.9 36.5 41.6 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 6.6 100 6.6 N.A. 100 0 N.A. 13.3 0 0 26.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 20 100 26.6 N.A. 100 0 N.A. 26.6 6.6 0 26.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 10 0 0 0 0 0 20 0 0 0 0 0 0 % A
% Cys: 0 30 0 0 0 0 0 0 0 0 20 0 10 0 0 % C
% Asp: 0 10 10 0 0 0 0 0 0 0 0 0 20 0 10 % D
% Glu: 10 10 0 20 40 0 10 0 0 0 0 10 0 10 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 10 0 0 10 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 10 0 0 0 0 0 0 0 10 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 10 10 10 0 0 % K
% Leu: 0 0 0 0 10 0 0 10 0 10 30 0 0 10 0 % L
% Met: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 10 0 0 10 0 0 30 0 0 % N
% Pro: 0 10 0 0 0 0 10 10 0 30 10 0 0 30 20 % P
% Gln: 0 0 0 10 0 0 30 0 0 0 10 0 0 10 0 % Q
% Arg: 10 0 0 10 0 10 0 0 30 0 0 10 0 0 30 % R
% Ser: 40 0 50 10 10 40 10 40 20 10 0 50 0 10 0 % S
% Thr: 10 0 0 30 10 10 0 10 10 0 0 0 10 0 0 % T
% Val: 10 10 0 0 0 10 10 0 0 10 0 0 0 10 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _